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new KR2i TFF System®
Tangential Flow Filtration System with Automated Process Controls
and Data Collection Software for R&D Scale Bioprocessing

The new, second generation KR2i TFF System [KrosFlo® Research 2i Tangential Flow Filtration System] is ideal for precise and reproducible control and documentation of Tangential Flow Filtration processes ranging from 1mL to 10 Liters. Highly configurable and versatile, the KR2i utilizes a number user-defined set-points to run complex application processes with numerous built-in safety alarms and stops. The fully integrated system consists of a digital peristaltic pump, man/machine interface with a graphical LCD display, digital pressure monitor, KR2i Easy-Load Pump head, Automatic Backpressure Valve, filter module stand, and KF Comm real-time data collection software. With the pump drive and Easy-Load Pump Head, the KR2i provides consistent and accurate flow rates up to 2.0 LPM. The system can run up to two stackable pump heads for higher flow rates.

The KR2i is designed to interface with a number of Auxiliary Scales and Pumps to enable automated process controls. There are six automated process modes:

  • Concentration Mode, may be used to simply concentrate the process solution but may also be used to automate flushing the hollow fiber filter before use
  • Concentration / Diafiltration Mode, may be used to concentrate and then diafilter the process solution in succession
  • Concentration / Diafiltration / Concentration Mode, can diafilter the process solution with two different buffers in succession before concentrating the process solution a second time
  • Concentration / Diafiltration / Diafiltration / Concentration Mode, can diafilter the process solution with two different buffers in succession before concentrating the process solution a second time
  • Constant Feed Concentration Mode, may be used to maintain a constant feed weight while concentrating the solution
  • Constant Feed Concentration / Diafiltration / Concentration Mode, may be used to maintain a constant feed weight while concentrating the solution, then wash the solution with a buffer during diafiltration, and then concentrate the process solution further
Part Number Description Price
SYR2-U20 KR2i Tangential Flow Filtration System includes a digital peristaltic pump, operator interface with graphical LCD display, digital pressure monitor, KR2i easy load pump head, module stand, Microsoft Surface Pro 4 and KF Comm data collection software. Additional accessories included are fitting kits, reservoirs, reservoir holders and tubing
 
Main Components
Digital Controlled Peristaltic Pump
  • IP 33 Enclosure
  • 600 PRM pump with reversible drive
  • 90-260 Vrms @ 50/60 Hz
  • Standard Easy Load 3 Pump Head for precision tubing L/S number 13, 14, 16, 25, 17, and 18 provided.
  • (Optional) Easy Load 3 pump head for high performance tubing L/S numbers 15, 24, 35, 36
  • ETL listed and CE Marked
  • Pump Drive Dimensions: 10.5 in x 8 in x 8 in
new KR2i Pump
High Performance
Standard Performance
Digital Pressure and Transducer
Digital Pressure Monitor and Transducers

Measures & displays 4 pressures

  • Inlet Pressure
  • Outlet Pressure
  • Permeate Pressure
  • Transmembrane Pressure (TMP)
User-defined pressure alarm and stop set-points

Inline or Luer Polysulfone Pressure Sensors
available from SpectrumLabs.com

New Automatic Backpressure Valve

SpectrumLabs.com's New KrosFlo Automatic Backpressure Valve (ABV) automatically adjusts its pinch distance to exert and maintain a user-defined set-point for the Inlet, Outlet, Permeate, or Transmembrane Pressures when attached to the process flow path. The new Automatic Backpressure Valve can be used with tubing sizes 13, 14, 16, 25, HP15, 17, HP24, 18, HP35, 36, HP36, 26, and 73. With more controls than ever, the new Automatic Backpressure Valve's start position when initiating pinching can be set to start pinching from the open, middle, or closed position. The ABV decreases the chance of membrane fouling by maintaining a uniform TMP throughout the process run, controls the Permeate pressure and flow during MF applications, reduces operator process management time and decreases tangential flow filtration processing time by maintaining a more uniform gel-layer.

Digital Pressure and Transducer
KF Comm Data Collection Software

Automatically collects process data and provides real-time overviews of the filtration process.

Records 12 real-time operating parameters:

Time

Inlet Pressure

Retentate Pressure

Permeate Pressure

Feed Flow Rate

Diafiltration Flow Rate ( with optional auxiliary pump)

Permeate Flow Rate ( with optional auxiliary pump)

Feed Scale Weight ( with optional auxiliary scale)

Permeate Scale Weight ( with optional auxiliary pump)

Pump RPM

Notes (Alarms, Process Status, Functions)

Pump Mode (7 Different Pump Modes)

Calculates 8 processing parameters

Transmembrane Pressure (TMP)

Pressure Drop (ΔP)

Permeate Flow Rate (with no optional auxiliary pump)

Retentate Flow Rate (with no optional auxiliary pump)

Flux

Volumetric Throughput (VT)

Concentration Factor

Shear

Surface Pro 4 image
Automatically graphs data in VBA-enabled Excel-based software

21CFR Part 11 enabled when used with optional KF Comm Compliant Workbook and interface software package from Ofni Systems (ExcelSafe)

Warranty

SpectrumLabs.com's KR2i TFF System meets strict quality control standards and is warranted against defects in material and workmanship for a period of two (2) years from date of shipment.

Accessories
Reservoirs

15ml Conical Bottom 3 port reservoir with bent inlet (ACBT-015-C1N)

50 ml Conical Bottom 3 port reservoir with bent inlet (ACBT-050-C1N)

250 ml Conical Bottom 3 port reservoir with bent inlet (ACBT-250-F1N)

500 ml Conical Bottom 3 port reservoir with bent inlet (ACBT-500-F2N)

Reservoir Holders

15 - 50ml Conical Bottom Reservoir Holder (ACPX-BHC-50)

250 - 500 ml Conical Bottom Reservoir Holder (ACPX-BHC-500)

Kits

KR2i Starter Kit

MicroKros® and MidiKros® Fittings Kits (ACPX-CD)

MiniKros® Sampler Fittings Kit must be purchased separately (ACPX-S-01N)

Tubing

Pharmapure® Tubing Size 14, 25' (ACTU-P14-25N)

Pharmapure® Tubing Size 16, 25' (ACTU-P16-25N)

Auxiliary Components
Different combinations of Auxiliary Components (scales, pumps, and valve) enable the KR2i to utilize automated Pump Mode for more efficient, repeatable bioprocessing applications.
Auxiliary Scales
The KR2i can be equipped with up to two Auxiliary Scales - one for the Process Reservoir and one for the Permeate Reservoir. learn more >
Auxiliary Pumps
The KR2i can be equipped with up to two Auxiliary Pumps that can be used as Constant Feed, Diafiltration and Permeate Pumps. learn more >
Warranty
SpectrumLabs.com's KR2i TFF System meets strict quality control standards and is warranted against defects in material and workmanship for a period of two (2) years from date of shipment.
hi dave
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